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临床中药学

李芸霞

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个人简介

李芸霞,中药学博士后,理学博士,研究员,博士生导师,药学院。四川省首批“天府万人计划”天府科技菁英,第八届全国高等中医药院校优秀青年,四川省学术和技术带头人后备人选,四川省中医药管理局学术和技术带头人后备人选;中华中医药学会中药基础理论分会常务委员,中国中西医结合学会基础理论专业委员会委员,四川省药学会药理与临床药理学专委会委员,四川省食品药品检验检测院国家药品监督管理局中成药质量评价重点实验室学术委员会委员等;《天然药物研究与开发》、《药学研究》杂志编委,主编Evidence-Based Complementary and Alternative Medicine 特刊, Phytomedicine、Journal of ethnopharmacology,Biomedicine &Pharmacotherapy 等杂志审稿人。

主要研究领域为在中医药理论指导下的中药有效性和安全性研究。秉承“系统中药”多维评价的指导思想,以中药的临床安全有效为核心出发点,围绕中药的品种、品质、药性、药效及应用等方面,引入和发展符合中药整体观的代谢组学和网络药理学等技术开展整体、器官、细胞不同层次研究,提出以药效为指标的中药成分标准化策略以及 “功效成分组”概念;以功效为核心构建多组分多靶点效应模型以及符合中药复杂特点的整合药动学药效学模型进行中药的有效性安全性科学内涵研究。

主持国家自然科学基金3项(面上项目:“司外揣内”活性成分谱桥接生物体代谢响应网络探究附子治疗心阳虚型慢性心衰的药效物质基础及作用机理,多组分多靶点动态网络调控驱动效应模型研究连翘"清热解毒"的药效物质基础和协同作用机理; 青年项目:连翘清热解毒药效物质基础的“谱证动力学”研究),四川省青年科技创新研究团队项目,四川省杰出青年基金等国家级部省级以上课题10项,另主研国家自然科学基金重点项目、国家重点基础研究发展计划(973计划)等10余项,在国内外知名学术期刊发表学术论文70余篇,其中SCI论文39篇(第一作者或通讯作者33篇),核心期刊论文31篇,编写教材专著4部,申请专利5项,获授权2项。

代表性成果

(1)代表性论著

1.Xinyan Xue, Yunyun Quan, Lihong Gong, Xiaohong Gong, Yunxia Li*. A review of the processed Polygonum multiflorum (Thunb.) for hepatoprotection: Clinical use, pharmacology and toxicology. J Ethnopharmacol. 2020: 113121. (期刊论文)

2.Naihua Hu, Jie Liu, Xinyan Xue, Yunxia Li*. The effect of emodin on liver disease -- comprehensive advances in molecular mechanisms. Eur J Pharmacol. 2020, 882: 173269. (期刊论文)

3.Lihong Gong, Linyuan Yu, Xiaohong Gong, Cheng Wang, Naihua Hu, Xuyang Dai, Cheng Peng*, Yunxia Li*. Exploration of anti-inflammatory mechanism of forsythiaside A and forsythiaside B in CuSO4-induced inflammation in zebrafish by metabolomic and proteomic analyses. J Neuroinflammation. 2020, 17(1): 173. (期刊论文)

4.Cheng Wang, Nai-Hua Hu, Lin-Yuan Yu, Li-Hong Gong, Xu-Yang Dai, Cheng Peng*, Yun-Xia Li*. 2,3,5,4'-tetrahydroxystilbence-2-O-β-D-glucoside attenuates hepatic steatosis via IKKβ/NF-κB and Keap1-Nrf2 pathways in larval zebrafish. Biomed Pharmacother. 2020, 127: 110138. (期刊论文)

5.Mengting Zhou, Naihua Hu, Meichen Liu, Ying Deng, Linfeng He, Chaocheng Guo, Xingtao Zhao, Yunxia Li*. A Candidate Drug for Nonalcoholic Fatty Liver Disease: A Review of Pharmacological Activities of Polygoni Multiflori Radix. Biomed Res Int. 2020, 2020: 5462063. (期刊论文)

6.Linyuan Yu, Lihong Gong, Cheng Wang, Naihua Hu, Yunqiu Tang, Li Zheng, Xuyang Dai, Yunxia Li*. Radix polygoni multiflori and its main component emodin attenuate non-alcoholic fatty liver disease in zebrafish by regulation of AMPK signaling pathway. Drug Des Devel Ther. 2020, 14: 1493-1506. (期刊论文)

7.Cheng Wang, Yimeng Zhou, Xiaohong Gong, Li Zheng, Yunxia Li*. In vitro and in situ study on characterization and mechanism of the intestinal absorption of 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside. BMC Pharmacol Toxicol. 2020, 21(1): 1-13. (期刊论文)

8.Naihua Hu, Cheng Wang, Xuyang Dai, Mengting Zhou, Lihong Gong, Lingyuan Yu, Cheng Peng∗, Yunxia Li∗. Phillygenin inhibits LPS-induced activation and inflammation of LX2 cells by TLR4/MyD88/NF-κB signaling pathway. J Ethnopharmacology. 2019, 248: 112361. (期刊论文)

9.Gong Xiaohong, Liu Meichen, Gong Lihong, Li Yunxia*, Peng Cheng*. Study on hepatotoxicity of different dosages of Polygoni multiflori radix praeparata in rats by metabolomics based on UPLC-Q-TOF-MS. J Pharm Biomed Anal. 2019, 175. (期刊论文)

10.Xie Yunfei, Feng Wuwen, Liu Meichen, Xie Jun, Yu Lei, Gong Xiaohong, Li Yun-Xia*, Peng Cheng*. Investigation of Efficacy Enhancing and Toxicity Reducing Mechanism of Combination of Aconiti Lateralis Radix Praeparata and Paeoniae Radix Alba in Adjuvant-Induced Arthritis Rats by Metabolomics. Evidence-based complementary and alternative medicine: eCAM. 2019: 9864841. (期刊论文)

11.Yunyun Quan, Lihong Gong, Junlin He, Yimeng Zhou, Meichen Liu, Zhixing Cao, Yunxia Li*, Cheng Peng*. Aloe emodin induces hepatotoxicity by activating NF-κB inflammatory pathway and P53 apoptosis pathway in zebrafish. Toxicology Letters. 2019, 306. (期刊论文)

12.Liu Meichen, Gong Xiaohong, Quan Yunyun, Zhou Yimeng, Li Yunxia*, Peng Cheng*. A Cell-Based Metabonomics Approach to Investigate the Varied Influences of Chrysophanol-8-O-β-D-Glucoside with Different Concentrations on L-02 Cells. Front Pharmacol, 2019, 9: 1530. (期刊论文)

13.Yunxia Li#, Xiaohong Gong#, Meichen Liu, Cheng Peng*, Peng Li*, Yitao Wang. Investigation of Liver Injury of Polygonum multiflorum Thunb.in Rats by Metabolomics and Traditional Approaches. Frontiers Pharmacol. 2017, 8: 791. (期刊论文)

14.Yan Li#, Yunxia Li#, Mengjie Zhao, An Yuan, Xiaohong Gong, Mengjun Zhao, Cheng Peng*. The Effects of Rheum palmatum L. on the Pharmacokinetic of Major Diterpene Alkaloids of Aconitum carmichaelii Debx. in Rats. European Journal of Drug Metabolism and Pharmacokinetics. 2017, 42(3): 441-451. (期刊论文)

(2)论著之外的代表性研究成果和学术奖励

1.李芸霞; 龚小红; 彭成; 党珏; 赵梦杰; 赵梦君; 罗林; 袁岸; 李燕, 生何首乌的HPLC指纹图谱检测方法, 2018.11.06-2038.11.06, 中国, 201610490084.0 (专利)

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