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中药药理学

徐世军

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个人简介

徐世军,医学博士、博士后、二级教授,博士研究生导师、目前所在学院-药学院。四川省学术与技术带头人,四川省卫生与计划生育委员会学术带头人,四川省中医药管理局学术带头人,成都中医药大学中药药理学学科学术带头人后备人选。四川省青年科技奖和四川省杰出青年基金获得者。兼任全国脑健康协作组/北京师范大学老年脑健康研究中心研究员,现任中华中医药学会中药实验药理学专委会常务委员、中国生理学会中医药与脑稳态专委会委员、世界中医药学会联合会脑病专委会常务理事,世界中医药学会联合会网络药理学专委会常务理事、世界中医药学会联合会上市药物再评价委员会常务理事等。兼任长江学者、国家“千人计划”青年项目、国家自然科学基金项目、中国博士后科学基金评审专家、香港特别行政区食物及卫生局研究基金评审专家及四川、重新、浙江和河北科技项目及科技奖励评审专家。主要研究方向为中药药效与毒理、神经退行性疾病创新药物发现与评价、痴呆风险因素早期发现与致病机制及中药抗炎与免疫药理等。先后获得国家自然科学基金(重点、面上)项目、“重大新药创制”科技重大专项、国家重点研发计划-中药现代化专项等科技项目10余项。围绕阿尔兹海默病(AD)风险因素及创新药物发现研究方向,首次发现并阐释了长期冰冻饮食导致认知损伤的致病机制,论文发表在该领域2区区杂志APS(IF:5.064);创新认知障碍新理论,系统研究并构建干预康复体系,“认知功能障碍的发生机制及中医康复技术应用研究”和“恐惧认知障碍的发生机制及针药意三结合康复体系应用研究”分别获得2016年及2019年度四川省科技进步二等奖(证书:2016-J-2-54-R02,2019-J-2-12-R01);首次发现了蜀椒、川芎等川药的新用途、新机制,论文发表于药理领域权威杂志Frontiers in Pharmacology(IF=4.22),Drug Design, Development and Therapy(IF=3.216);创制了通络醒脑泡腾片、参芪益智颗粒、天芪益智颗粒等AD新药(专利授权号ZL201310132096.2,ZL201310128021.7,ZL201711205034.4),建立了fMRI在体评价AD中药复方疗效的新方法,论文发表于该领域权威杂志Current Alzheimer Research. (IF:3.67)并入选Faculty of 1000。首次揭示了寒热痹的表观遗传学机制,并建立了多组学联用发现中药复方功效相关物质和机制研究新方法,论文发表于国际权威杂志International Immunopharmacology(IF=3.943)等。近年正式发表学术论文100余篇,其中SCI 10余篇,IF>5分论文1篇,>3分7篇;获四川省科技进步二等奖2项、三等奖1项,成都市科技进步三等奖1项;获得国家发明专利10项,转让专利2项;出版教材专著18部,其中主编的《实用临床药物学-中成药卷》是自《临床药物学》1954年第一版出版以来第一次纳入中成药;获得中药新药临床批件1件。


代表性成果

1. Lijuan Ga*, Xiaoqiong Li*, Shi Meng*, Tengyun Ma,Lihong Wan#, Shijun Xu#.Chlorogenic Acid Alleviates Aβ25-35-Induced Autophagy and Cognitive Impairment via the mTOR/TFEB Signaling Pathway.Drug Design, Development and Therapy. 2020:14 1705–1716(IF=3.216)

2. Jiang-ping Wei1, Wen Wen, Yuan Dai, Li-xia Qin, Yue-qiang Wen, Dayue Darrel Duan# and Shi-jun Xu#.Drinking water temperature affects cognitive function and progression of Alzheimer’s disease in a mouse model.Acta Pharmacologica Sinica (2020) 0:1–10(IF=5.064)

3. Panwang Liu*, Jie Wang*, Wen Wen*, Ting Pan, Huan Chen, Ying Fu, Fushun Wang, Jason H. Huang, Shijun Xu# Cinnamaldehyde suppresses NLRP3 derived IL-1β via activating succinate/HIF-1 in rheumatoid arthritis rats .International Immunopharmacology.84 (2020) 106570(IF=3.943)

4.Meihuan Zhao*,Xueqian Tang*, Daoying Gong*, Peng Xia, Fushun Wang#,Shijun Xu1#.Bungeanum Improves Cognitive Dysfunction and Neurological Deficits in D-Galactose-Induced Aging Mice via Activating PI3K/Akt/ Nrf2 Signaling Pathway. Frontiers in Pharmacology.2020;doi:10.3389/fphar.2020.00071 (IF=4.225)

5.Wen W*,Chen H*, Fu K*, Wei J, Qia L, Pan T, Xu S#. Viticies Fructus methanol extract improves trigeminal hyperalgesia in migraine by regulating injury signal transmission[J]. Exp Ther Med. 2020.19:85-94;DOI: 10.3892/etm.2019.8201(IF=1.785)

6. Jiangping Wei*, Lixia Qin, Ying Fu, Yuan Dai, Yueqiang Wen Shijun Xu#.Long-term consumption of alcohol exacerbates neural lesions by destroying the functional integrity of the blood–brain barrier. DRUG AND CHEMICAL TOXICOLOGY.2019;.doi.10.1080/01480545.  (IF=1.946)

7. Huan Chen,Ting Pan, Panwang Liu, Ping Wang#, Shijun Xu#. Baihu Jia Guizhi Decoction Improves Rheumatoid Arthritis Inflammation by Regulating Succinate/SUCNR1 Metabolic Signaling Pathway. Evidence-Based Complementary and Alternative Medicine Volume 2019, Article ID 3258572, 11(IF=1.984)

8.Shen C Yang C, Xu S#,Zhao H#. Comparison of osteogenic differentiation capacity in mesenchymal stem cells derived from human amniotic membrane (AM), umbilical cord (UC), chorionic membrane (CM), and decidua (DC)[J]. Cell Biosci, 2019,https://doi.org/10.1186/s13578-019-0281-3  (IF=3.355)

9. Han B*, Dai Y*, Wu H, Zhang Y, Wan L, Zhao J, Liu Y, Xu S#, ZhouL#.. Cimifugin Inhibits Inflammatory Responses of RAW264. 7 Cells Induced by Lipopolysaccharide[J]. Medical science monitor:, 2019, 25: 409-417. doi: 10.12659/MSM.912042(IF=1.98)

10. Fu, W. *, Dai, Y*., Ma, T*., Wei, J., Chen, H., Xu, S#. Tongluo Xingnao effervescent tablet reverses memory deficit and reduces plaque load in APPswe/PS1dE9 mice". Experimental and Therapeutic Medicine 15.4 (2018): 4005-4013. (IF=1.448)

11.Yuan Dai *, Tao Ma *, Xiangyi Ren*, Jiangping Wei, Wenjun Fu, Yuntong Ma, Shijun Xu#, Zhanjun Zhang。 Tongluo Xingnao Effervescent Tablet preserves mitochondrial energy metabolism and attenuates cognition deficits in APPswe/PS1De9 mice[J]. Neuroscience letters, 2016, 630: 101-108.  (IF=2.18)

12. Ren, X, Wei, J., Gong, D., Hu, Y., Chen, H., Xu, S # Tongluoxingnao effervescent tablets ameliorate learning and memory impairment in a rat model of vascular dementia via the regulation of the p38 and ERK MAPK signaling pathways[J]. Int J Clin Exp Med, 2016, 9(3): 5400-5412.   (IF=1.069)

13.Ying Lian*, Xuan Sun*, Shijun Xu* Yaou Liu, Ruiwang Huang, Jianjun Jia and Zhanjun Zhang#. Preclinical cerebral network connectivity evidence of deficits in mild white matter lesions[J]. Frontiers in aging neuroscience, 2016, 8: doi: 10.3389/fnagi.2016.00027  (IF=4.504)

14. Junying Zhang*, Zijing Wang*, Shijun Xu*, Yaojing Chen, Kewei Chen, Li Liu, Yongyan Wang, Rongjuan Guo and Zhanjun Zhang#. The effects of CCRC on cognition and brain activity in aMCI patients: a pilot placebo controlled BOLD fMRI study[J]. Current Alzheimer Research, 2014, 11(5): 484-493. ( IF=3.67)

15.徐世军.实用临床药物学-中成药卷.北京:中国医药科技出版社,2019


终审:药学院管理员
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