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四川省学术和技术带头人

韩波

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通讯地址:成都市温江区柳台大道1166号成都中医药大学药学楼1202

联系方式:hanbo@cdutcm.edu.cn

韩波,二级教授,博士生导师,成都中医药大学药学院院长,美国纽约州立大学RNA研究所访问学者。入选国家级优秀人才计划、国家中医药管理局“青年岐黄学者”、四川省学术与技术带头人,四川省中医药管理局学术带头人、省部级优秀人才计划入选者、四川省卫生健康领军人才。先后荣获全国百篇优秀博士论文奖、中华医学青年科技奖、四川省科技进步一等奖、四川省杰出青年科学技术创新奖、四川省青年科技奖等荣誉。

       研究方向为中药药效物质的结构优化、分子网络机制、多维构效关系和创新药物研发。以临床疗效显著的经典中药药效成分为研究对象,融合多层次的药物结构信息与活性数据,系统研究药效成分“构-效-毒”的多维关系,以此开展药物筛选和创新药物设计开发。

       作为负责人,主持国家自然科学基金(面上项目3项及青年基金1项,主研重点项目1项)、十三五“重大新药创制”科技重大专项、四川省科技重大前沿项目等十余项国家及省部级科研项目。以第一或通讯作者身份在国际主流SCI期刊发表研究论文九十余篇,其中,IF大于60论文1篇,IF大于10论文14篇,IF大于5论文60余篇,引用次数大于100论文4篇,ESI高被引论文3篇,Nature Index自然指数期刊论文19篇。获得授权专利14项;参与制定国际标准1项。主编 “十四五”规划教材《药物化学》、《药学概论》和《药物化学实验》、;参编中文专著1部;参与制定国际标准1项。

       目前担任世界中医药学会联合会道地药材多维评价专业委员副会长、四川省药学会药学教育专委会副主任委员、四川省药学专业教学指导委员会副主任委员、四川省药学会副理事长、四川省医药科技促进会副会长、《Frontiers in Catalysis》副主编、《The Innovation》青年编委、中国科技期刊卓越行动计划项目《中华中医药杂志》青年编委、《中国抗生素杂志》编委、《Anticancer Agents in Medicinal Chemistry》编委、Current Topics in Medicinal Chemistry期刊客座主编、世界中医药学会联合会中药化学专业委员会理事、四川省专家评议委员会委员、四川省科技青年联合会理事、成渝地区双城经济圈科技创新联盟项目评估咨询专家、成都市青年联合会委员、成都市药学会常务理事、成都市知联会医药卫生专委会秘书长等。

       组织本科生参加各级各类科研课题100余项,参与发表SCI论文二十余篇,并作为指导老师指导学生在教育部药学/中药学教指委举办的全国性级科研创新、实践技能、创新创业竞赛中取得优异成绩,如第六届及第八届全国大学生药苑论一等奖;第六届全国医药院校药学/中药学专业大学生实验技能竞赛特等奖、第二届大学生实验技能暨创新创业大赛一等奖;第十二届“全国大学生药苑论坛”特等奖及一等奖等。此外,候选人作为研究生导师,培养11名同学共计16次获得“国家奖学金”,4名同学获四川省优秀毕业生荣誉称号,6名同学获校级优秀毕业生荣誉称号。2013至今,指导研究生共计16次获得“研究生国家奖学金”,指导的硕士/博士研究生以第一作者身份,发表SCI收录的科研论文64篇,其中IF大于10的论文5篇,IF大于5的论文36篇。

 

※ 部分负责项目

1.         国家自然科学基金委员会,面上项目,82073998,山茱萸环烯醚萜调控自噬-炎症相互作用治疗糖尿病肾病的机制和多维构效关系,2021.01-2024.12,55.00万元,主持

2.         国家自然科学基金委员会,面上项目,81773889,马钱子生物碱诱导程序性细胞死亡的“效与毒”整合作用机制以及立体构效关系研究,2018.01-2021.12,60.00万元,主持

3.         中国科技部,"重大新药创制"十三五 科技重大专项,2018ZX09721001-008-002,中药防治耐药菌创新结构药物研发,2018.01-2020.12,799.50万元,主持

4.         四川省科学技术厅,应用基础研究重大前沿项目,2017JY0323,中药防治耐药菌新品种筛选及关键创新技术建立,2017.01-2020.12,50.00万元,主持

5.         国家自然科学基金委员会,面上项目,81573588,钩藤生物碱调控α-突触核蛋白依赖的自噬-溶酶体途径治疗帕金森病的作用机制和构效关系研究,2016.01-2019.12,57.00,主持

6.         四川省科学技术厅,杰出青年基金,2014JQ0020,基于“立体构效关系模型”融合生物信息学研究青黛治疗慢粒白血病的药效物质基础和分子机制,2014.01-2016.12,50.00万元,主持

7.         国家自然科学基金委员会,青年项目,21302016,基于双催化体系不对称合成结构多样性杂环骨架,2014.01-2016.12,25.00,主持

 

※ 代表性成果

1.         Zou, W.-L.; Liu, Y.-Q.; Li, Q.-Z.; Kou, X.-X.; Huang, H.; Tong, R.-S.; Li, J.-L.; Han, B.*, Dearomative tandem annulation to access chiral indoline-fused bicyclo 2.2.2 octanes using modularly designed organocatalysts. Organic Chemistry Frontiers 2023. 中科院一区,IF: 5.456

2.         Zhu, H.-P.; Chai, J.; Qin, R.; Leng, H.-J.; Wen, X.; Peng, C.; He, G.; Han, B.*, Discovery of tetrahydrofuranyl spirooxindole-based SMYD3 inhibitors against gastric cancer via inducing lethal autophagy. European Journal of Medicinal Chemistry 2023, 246. 中科院一区,IF: 7.088

3.         Zhou, J.; Chen, C.; Pang, Q.; Zuo, W.-F.; Li, X.; Zhan, G.; Yang, Q.-Q.; Han, B.*, Cooperative photoactivation/Lewis base catalyzed 4+2 annulations of alpha-diazoketones and ortho-amino MBH carbonates to access dihydroquinolinone frameworks. Organic Chemistry Frontiers 2023. 中科院一区,IF: 5.456

4.         Qin, R.; You, F.-M.; Zhao, Q.; Xie, X.; Peng, C.; Zhan, G.; Han, B.*, Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets. Journal of Hematology & Oncology 2022, 15 (1). 中科院一区,IF: 23.168

5.         Peng, F.; Liao, M.; Qin, R.; Zhu, S.; Peng, C.; Fu, L.; Chen, Y.; Han, B.*, Regulated cell death (RCD) in cancer: key pathways and targeted therapies. Signal Transduction and Targeted Therapy 2022, 7 (1). 中科院一区,IF: 38.104

6.         Pang, Q.; Zhou, J.; Wu, Y.; Zhou, W.-J.; Zuo, W.-F.; Zhan, G.; Han, B.*, Construction of oxo-bridged diazocines via rhodium-catalyzed (4+3) cycloaddition of carbonyl ylides with azoalkenes. Organic Letters 2022, 24 (6), 1362-1366. 中科院一区,IF: 6.072

7.         Luo, Q.; Tian, Z.; Tang, J.; Wang, J.; Tian, Y.; Peng, C.; Zhan, G.; Han, B.*, Design and application of chiral bifunctional 4-pyrrolidinopyridines: Powerful catalysts for asymmetric cycloaddition of allylic N-ylide. Acs Catalysis 2022, 12 (12), 7221-7232. 中科院一区,IF: 13.700

8.         Luo, M.-L.; Hou, Q.; Liu, S.-J.; Zhao, Q.; Qin, R.; Peng, C.; Han, B.*; Zhan, G., One-step synthesis of hydropyrrolo 3,2-b indoles via cascade reactions of oxindole-derived nitrones with allenoates. Organic Letters 2022. 中科院一区,IF: 6.072

9.         Liao, M.; Qin, R.; Huang, W.; Zhu, H.-P.; Peng, F.; Han, B.*; Liu, B., Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies. Journal of Hematology & Oncology 2022, 15 (1). 中科院一区,IF: 23.168

10.      Li, H.-P.; He, X.-H.; Peng, C.; Li, J.-L.; Han, B.*, A straightforward access to trifluoromethylated natural products through late-stage functionalization. Natural Product Reports 2022. 中科院一区, IF: 15.111

11.      Li, D.-A.; He, X.-H.; Tang, X.; Wu, Y.; Zhao, H.; He, G.; Peng, C.; Han, B.*; Zhan, G., Organo/silver dual catalytic (3+2)/Conia-Ene type cyclization: asymmetric synthesis of indane-fused spirocyclopenteneoxindoles. Organic Letters 2022, 24 (33), 6197-6201. 中科院一区,IF: 6.072

12.     He, X.-H.; Fu, X.-J.; Zhan, G.; Zhang, N.; Li, X.; Zhu, H.-P.; Peng, C.; He, G.; Han, B.*, Organocatalytic asymmetric synthesis of multifunctionalized alpha-carboline-spirooxindole hybrids that suppressed proliferation in colorectal cancer cells. Organic Chemistry Frontiers 2022, 9 (4), 1048-1055. 中科院一区,IF: 5.456

13.     Han, B.; He, X.-H.; Liu, Y.-Q.; He, G.; Peng, C.*; Li, J.-L.* Asymmetric organocatalysis: an enabling technology for medicinal chemistry. Chemistry Society Review 2021, 50, 1522. 中科院一区,IF: 60.615

14.     Wang, B.; Peng, F.; Huang, W.; Zhou, J.; Zhang, N.; Sheng, J.; Haruehanroengra, P.; He, G.*; Han, B.* Rational drug design, synthesis, and biological evaluation of novel chiral tetrahydronaphthalene-fused spirooxindole as MDM2-CDK4 dual inhibitor against glioblastoma, Acta Pharmaceutica Sinica B, 2020, 10,1492. 中科院一区,IF: 14.903

15.     Peng, F.; Zhao, Q.; Huang, W.; Liu, S.-J.; Zhong, Y.-J.; Mao, Q.; Zhang, N.; He, G.*; Han, B.* Amine-catalyzed and functional group-controlled chemo- and regioselective synthesis of multi-functionalized CF3-benzene via a metal-free process. Green Chemistry 2019, 21 (22), 6179. 中科院一区,IF: 11.034

16.     Zhang, X.; Li, Xiang.; Li, J.-L.*; Wang, Q.-W.; Zou, W.-L.; Liu, Y.-Q.; Jia, Z.-Q.; Peng, F.*; Han, B.* Regiodivergent construction of medium-sized heterocycles from vinylethylene carbonates and allylidenemalononitriles. Chemical Science 2020, 11, 2888. 中科院一区,IF: 9.969

17.     Liu, S.-J.; Zhao, Q.; Peng, C.; Mao, Q.; Wu, F.; Zhang, F.-H.; Feng, Q.-S.; He, G.; Han, B.* Design, synthesis, and biological evaluation of nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation. European Journal of Medicinal Chemistry 2021, 217, 113359. 中科院一区,IF: 7.088

18.     Xie, X.; Xiong, S.-S.; Li, X.; Huang, H.; Wu, F.-B.; Shen, P.-F.; Peng, C.*; G.; He*, Han, B.* Design and organocatalytic synthesis of spirooxindole–cyclopentene–isoxazole hybrids as novel MDM2–p53 inhibitors. Organic Chemistry Frontiers 2021, 8, 1836. 中科院一区,IF: 5.456

19.     Zuo, W.-F.; Zhou, J.; Wu, Y.-L.; Fang, H.-Y.; Lang, X.-J.; Li, Y.; Zhan, G.*; Han, B.* Synthesis of spiro(indoline-2,3’-hydropyridazine) via an “on-water” [4 + 2] annulation reaction. Organic Chemistry Frontiers 2021, 8, 922. 中科院一区,IF: 5.456

20.     Zhang, N.; Peng, F.; Wang, Y.; Yang, L.; Wu, F.; Wang, X.; Ye, C.; Han, B.*; He, G.* Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis. International Journal of Biological Sciences 2020, 16, 147. 中科院二区,IF: 10.750

21.     Ji, Y.-L.; He, X.-H.; Li, G.; Ai, Y.-Y; Li, H.-P.; Peng C.; Han, B.* Substrate-directed chemo- and regioselective synthesis of polyfunctionalized trifluoromethyl-arenes via organocatalytic benzannulation. Organic Chemistry Frontiers 2020, 7, 563. 中科院一区,IF: 5.456

22.     Tang, X.; Zhang, N.; He, G.*; Li, C.-H.; Huang, W.; Wang, X.-Y.; Zhan, G*.; Han, B.* Unconventional [2 + 3] cyclization involving [1,4]-sulfonyl transfer to construct polysubstituted fluorazones as inhibitors of indoleamine 2,3-dioxygenase 1. Organic Letters 2020, 22, 7909. 中科院一区,IF: 6.072

23.     Han, B.; Xiao, Y.-C.; Yao, Y.; Chen, Y.-C.* Lewis acid catalyzed intramolecular direct ene reaction of indoles. Angewandte Chemie-International Edition 2010, 49, 10189. 中科院一区,IF: 16.832

24.     Han, B.; He, Z.-Q.; Li, J.-L.; Li, R.; Jiang, K.; Liu, T.-Y.; Chen, Y.-C.* Organocatalytic regio- and stereoselective inverse-electron-demand Aza-Diels–Alder reaction of α,β-unsaturated aldehydes and N-tosyl-1-aza-1,3-butadienes. Angewandte Chemie-International Edition 2009, 48, 5474. 中科院一区,IF: 16.832

Han, B.; Li, J.-L.; Ma, S.; Zhang, S.-J.; Chen, Y.-C.* Organocatalytic asymmetric inverse-electron-demand Aza-Diels-Alder reaction of N-sulfonyl-1-aza-1,3-butadienes and aldehydes. Angewandte Chemie-International Edition 2008, 47, 9971. 中科院一区,IF: 16.832


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