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中药化学方向

黎胜红

个人简介

黎胜红,博士,二级研究员,博士/硕士研究生导师,现为成都中医药大学副校长,国家杰出青年基金、国务院政府津贴、德国洪堡奖学金获得者,国家“万人计划”领军人才、科技部中青年科技创新领军人才、中科院“百人计划”(A类)等入选者。目前主要学术兼职包括国家天然药物工程技术研究中心技术委员会委员,中国中药协会中药材检测认证技术专业委员会委员,中国植物学会植物化学和资源学专业委员会委员,中国植物生理与分子生物学学会植物代谢专业委员会委员,中国生态学会化学生态专业委员会委员,中国植物保护学会常务理事/植物化感作用专业委员会主任委员,广西植物功能物质研究与开发重点实验室学术委员会副主任委员,国际期刊Frontiers in Plant Science(IF=4.4)、Chemistry & Biodiversity(IF=2.0)、Plant Communications(Cell Press)、Natural Products and Bioprospecting(Springer)的副主编或编委以及30余个SCI国际期刊的审稿人等。

研究方向:长期从事植物天然产物结构、功能与生物合成等相关研究。国际上率先建立和运用单细胞水平植物天然产物研究新技术方法LMD-cryoNMR-UPLC/MS/MS,揭示了云杉韧皮薄壁细胞和石细胞中的酚类防御物质,并为精确定位活性天然产物在植物体内的合成、运输和积累等开辟了新途径。系统开展植物腺毛中的活性天然产物研究,发现两个家族的系列新奇骨架并具有重要防御功能和抗炎免疫活性的二倍半萜类化合物130余个,在国际化学顶级期刊Angew. Chem. Int. Ed.(IF=12.9)上发表我国大陆首篇植物化学研究论文,并受邀在天然产物领域权威综述期刊Nat. Prod. Rep.(IF=12.0)发表长篇综述。鉴定了植物二倍半萜生物合成途径的关键酶GFDPS,揭示二倍半萜是在质体中通过MEP途径生物合成得到以及GFDPS从GGDPS通过正选择进化而来,填补了国际上对植物二倍半萜生物合成认识的缺失,以封面文章发表在国际植物学顶级期刊Plant Cell(IF=9.6)上。研究工作有力促进了植物化学研究向超微量、高精确度和多学科交叉方向发展。从30余种药用及特色资源植物中发现新化合物600余个,活性化合物40余个,为相关植物资源的合理利用奠定了重要物质基础和科学依据,其中抗肿瘤活性降二萜Maoecrystal V等引起了国际著名有机化学家们的长期极大关注与全合成研究。迄今在国际主流SCI期刊发表研究论文120余篇,其中第一作者及通讯(含共通)作者论文62篇,累计影响因子>200。获授权发明专利7项,以副主编出版专著1部,参编著作2部。培养毕业博士10名和毕业硕士15名,其中1人获得中国科学院院长特别奖,1人获得中国科学院院长优秀奖,1人获得中国科学院优秀博士学位论文。

代表性成果

主持的代表性科研项目

国家自然科学基金重点项目(编号:21937006),新颖结构植物二倍半萜的发现与免疫抑制活性研究,2020/01-2024/12,360万元;

云南生物医药重大科技专项(编号:2019ZF011-2),重楼皂苷等重要植物药单体化合物生物合成途径关键技术研究,2019/01-2021/12,600万元;

云南省创新团队人才项目(编号:2018HC012),活性天然产物发现与生物合成,2017/08-2020/08,100万元;

国家自然科学基金面上项目(编号:31770390),重要药用唇形科植物腺毛中的活性天然产物研究,2018/01-2021/12,78万元;

国家杰出青年科学基金项目(编号:31525005),植物特殊结构中的次生代谢产物与生物功能,2016/01-2020/12,400万元;

NSFC-云南联合基金重点项目(编号:U1202263),云南特征唇形科植物的萜类次生代谢产物化学及防御功能研究,2013/01-2016/12,185万元;

国家重点基础研究计划(973)子课题(编号:2013CB127505),植物源杀线虫活性化合物的发掘及作用机制研究,2013/01-2017/12,100万元;

代表性论文

Yan Liu, Shihong Luo, Juan Hua, Desen Li, Yi Ling, Qian Luo, Shenghong Li*. “Characterization of defensive cadinenes and a novel sesquiterpene synthase responsible for their biosynthesis from the invasive Eupatorium adenophorum”. New Phytologist, 2021, 229, 1740–1754.

Kai Guo, Yan Liu, Shihong Luo, Yanchun Liu, Desen Li, Wenyuan Li, Shenghong Li*. “Detoxification of plant aromatic abietanoids via cleavage of the benzene ring into 11,12-seco-diterpene polyenes by a specialist insect of Leucosceptrum canum”. Organic Letters, 2020, 22, 126–129.

Kai Guo, Xin Liu, Tingting Zhou, Yanchun Liu, Yan Liu, Qiumei Shi, Xiaonian Li, Shenghong Li*. “Gentianelloids A and B: Immunosuppressive 10,11-seco-gentianellane sesterterpenoids from the traditional Uighur medicine Gentianella turkestanorum”, The Journal of Organic Chemistry, 2020, 85, 5511–5515.

Hao Geng, Yanchun Liu, Desen Li, Chaojiang Xiao, Yan Liu, Xiaonian Li, Shenghong Li*. “Unusual glycosidic labdane diterpenoids with cytotoxicity from the root of Phlomoides betonicoides”. Phytochemistry, 2020, 173, 112325.

Ting Tang, Chunhuan Li, Desen Li, Shuxi Jing, Juan Hua, Shihong Luo, Yan Liu*, Shenghong Li*. “Peltate glandular trichomes of Colquhounia vestita harbor diterpenoid acids that contribute to plant adaptation to UV radiation and cold stresses”. Phytochemistry, 2020, 172, 112285.

Wenyuan Li, Yan Liu, Yutian Lin, Yanchun Liu, Kai Guo, Xiaonian Li, Shihong Luo*, Shenghong Li*. “Antibacterial harziane diterpenoids from a fungal symbiont Trichoderma atroviride isolated from Colquhounia coccinea var. mollis”. Phytochemistry, 2020, 170, 112198.

Qingpu Huang, Kai Guo, Yan Liu, Yanchun Liu, Wenyuan Li, Hao Geng, Ying Wang, Shenghong Li*. “Diterpenoids and flavonoids from the twigs of Cephalotaxus fortunei var. alpine”. Chemistry& Biodiversity, 2020, 17, e2000210.

Liuqiong Luo, Yuegui Chen, Desen Li, Yan Liu*, Shenghong Li*. “Production of the inaccessible sesquiterpene (−)-5-epieremophilene by metabolically engineered Escherichia coli”. Chemistry& Biodiversity, 2020, 17, e2000219.

Yan Liu, Shuxi Jing, Shihong Luo, Shenghong Li*. “Non-volatile natural products in plant glandular trichomes: chemistry, biological activities and biosynthesis”, Natural Product Reports, 2019, 36, 626–665.

Yonghong Chen, Jiangbo He, Xue Bai, Xiaonian Li, Lanfeng Lu, Yanchun Liu, Keqin Zhang*, Shenghong Li*, Xuemei Niu*. “Unexpected biosynthesis of fluorescein-like arthrocolins against resistant strains in an engineered Escherichia coli”, Organic Letters, 2019, 21, 6499–6503.

Fei Luo, Yi Ling, Desen Li, Ting Tang, Yanchun Liu, Yan Liu*, Shenghong Li*. “Characterization of a sesquiterpene cyclase from the glandular trichomes of Leucosceptrum canum for sole production of cedrol in Escherichia coli and Nicotiana benthamiana”, Phytochemistry, 2019, 162, 121–128.

Ling Feng, Yu Zhang, Yanchun Liu, Yan Liu, Shihong Luo, Chunshuai Huang, Shenghong Li*. “Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum”, Bioorganic & Medicinal Chemistry, 2019, 27, 442–446.

Chunhuan Li, Jiayao Zhang, Xiuyun Zhang, Shenghong Li*, Jinming Gao*. “An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years”, European Journal of Medicinal Chemistry, 2019, 166, 400–416.

Kai Guo, Yanchun Liu, Yan Liu, Shihong Luo, Wenyuan Li, Xiaonian Li, Shenghong Li*. “Diversified abietane family diterpenoids from the leaves of Leucosceptrum canum and their cytotoxic activity”, Phytochemistry, 2019, 157, 43–52.

Guowei Zheng, Shihong Luo, Shifei Li, Juan Hua, Weiqi Li*, Shenghong Li*. “Specialized metabolites from Ageratina adenophora and their inhibitory activities against pathogenic fungi”, Phytochemistry, 2018, 148, 57–62.

Yu Zheng, Chaojiang Xiao, Kai Guo, Ying Wang, Yan Liu, Shihong Luo, Xiaonian Li, Shenghong Li*. “Lobarioid A, unusual antibacterial depsidone possessing an eight-membered diether ring from the edible lichen Lobaria sp.”, Tetrahedron Letters, 2018, 59, 743–746.

Linlin Teng, Tianyang Song, Zifei Xu, Xiao Liu, Rong Dai, Yonghong Chen, Shenghong Li*, Keqin Zhang*, Xuemei Niu*. “Selected mutations revealed intermediates and key precursors in the biosynthesis of polyketide-terpenoid hybrid sesquiterpenyl epoxy-cyclohexenoids”, Organic Letters, 2017, 19, 3923–3926.

Chaojiang Xiao, Yanchun Liu, Shihong Luo, Juan Hua, Yan Liu*, Shenghong Li*. “Localization of two bioactive labdane diterpenoids in the peltate glandular trichomes of Leonurus japonicus by laser microdissection coupled with UPLC-MS/MS”, Phytochemical Analysis, 2017, 28, 404–409.

Juan Hua, Yan Liu, Chao-Jiang Xiao, Shuxi Jing, Shihong Luo*, Shenghong Li*. “Chemical profile and defensive function of the latex of Euphorbia peplus”, Phytochemistry, 2017, 136, 56–64.

Juan Hua, Shihong Luo, Yan Liu, Yanchun Liu, Yanyun Tan, Ling Feng, Chaojiang Xiao, Keqin Zhang*, Shenghong Li*, Xuemei Niu*. “New bioactive macrocyclic diterpenoids from Euphorbia helioscopia”, Chemsitry & Biodiversity, 2017, 14, e1700327.

Yan Liu, Shihong Luo, Axel Schmidt, Guodong Wang, Guiling Sun, Marcus Grant, Ce Kuang, Minjie Yang, Shuxi Jing, Chunhuan Li, Bernd Schneider, Jonathan Gershenzon, Shenghong Li*. “A geranylfarnesyl diphosphate synthase provides the precursor for sesterterpenoid (C25) formation in the glandular trichomes of the mint species Leucosceptrum canum”, Plant Cell, 2016, 28, 804–822. (Cover article)

Fengwei Ma, Bing Xia, Shihong Luo, Shenghong Li*, Yan Zhou*. “Analysis of the lithiated leucosceptroids from Leucosceptrum canum to facilitate their identification and differentiation by electrospray ionization tandem mass spectrometry”, Rapid Communications in Mass Spectrometry, 2016, 30, 100–110.

Ying Wang, Shihong Luo, Juan Hua, Yan Liu, Shuxi Jing, Xiaonian Li, Shenghong Li*. “Capitate gandular trichomes of Paragutzlaffia henryi harbor new phytotoxic labdane diterpenoids”, Journal of Agricultural and Food Chemistry, 2015, 63, 10004–10012.

Shihong Luo, Cedric L. Hugelshofer, Juan Hua, Shuxi Jing, Chunhuan Li, Yan Liu, Xiaonian Li, Xu Zhao, Thomas Magauer*, Shenghong Li*. “Unraveling the metabolic pathway in Leucosceptrum canum by isolation of new defensive leucosceptroid degradation products and biomimetic model synthesis”, Organic Letters, 2014, 16, 6416–6419.

Chunhuan Li, Yan Liu, Juan Hua, Shihong Luo, Shenghong Li*. “Peltate glandular trichomes of Colquhounia seguinii harbor new defensive clerodane diterpenoids”, Journal of Integrative Plant Biology, 2014, 56, 928–940.

Shuxi Jing, Shihong Luo, Chunhuan Li, Juan Hua, Yanli Wang, Xuemei Niu, Xiaonian Li, Yan Liu, Chunshuai Huang, Ying Wang, Shenghong Li*. “Biologically active dichapetalins from Dichapetalum gelonioides”, Journal of Natural Products, 2014, 77, 882–893.

Jieyun Cai, Duozhi Chen, Shihong Luo, Ningchuan Kong, Yu Zhang, Yingtong Di, Qiang Zhang, Juan Hua, Shuxi Jing, Shunlin Li, Shenghong Li*, Xiaojiang Hao*, Hongping He*. “Limonoids from Aphanamixis polystachya and their antifeedant activity”, Journal of Natural Products, 2014, 77, 472–482.

Chunhuan Li, Shuxi Jing, Shihong Luo, Wei Shi, Juan Hua, Yan Liu, Xiaonian Li, Bernd Schneider, Jonathan Gershenzon, Shenghong Li*. “Peltate glandular trichomes of Colquhounia coccinea var. mollis harbor a new class of defensive sesterterpenoids”, Organic Letters, 2013, 15, 1694–1697.

Shihong Luo, Juan Hua, Xuemei Niu, Yan Liu, Chunhuan Li, Yanying Zhou, Shuxi Jing, Xu Zhao, Shenghong Li*. “Defensive Sesterterpenoid Lactones from Leucosceptrum canum”, Phytochemistry, 2013, 86, 29–35.

Shihong Luo, Juan Hua, Chunhuan Li, Yan Liu, Xiaonian Li, Xu Zhao, Shenghong Li*. “Unusual antifeedant spiro-sesterterpenoid from the flowers of Leucosceptrum canum”, Tetrahedron Letters, 2013, 54, 235–237.

Shenghong Li, Shengxiang Qiu, Ping Yao, Handong Sun, Harry H. S. Fong, Hongjie Zhang*. “Compounds from the fruits of the popular European medicinal plant Vitex agnus-castus in chemoprevention via NADP(H):quinone oxidoreductase type 1 induction”, Evidence-Based Complementary and Alternative Medicine, 2013, Article ID 432829.

Shenghong Li, Nina Elisabeth Nagy, Almuth Hammerbacher, Paal Krokene, Xuemei Niu, Jonathan Gershenzon, Bernd Schneider. “Localization of phenolics in phloem parenchyma cells of Norway spruce (Picea abies)”, ChemBioChem, 2012, 13, 2707–2713.

Shihong Luo, Juan Hua, Chunhuan Li, Shuxi Jing, Yan Liu, Xiaonian Li, Xu Zhao, Shenghong Li*. “New antifeedant C20 terpenoids from Leucosceptrum canum”, Organic Letters, 2012, 14, 5768–5771.

Shihong Luo, Yan Liu, Juan Hua, Xuemei Niu, Shuxi Jing, Xu Zhao, Bernd Schneider, Jonathan Gershenzon, Shenghong Li*. “Unique proline-benzoquinone pigment from the colored nectar of “bird’s Coca cola tree” functions in bird attractions”, Organic Letters, 2012, 14, 4146-4149.

Wei Shi, Shihong Luo, Shenghong Li*. “Defensive sesquiterpenoids from leaves of Eupatorium adenophorum”, Chinese Journal of Chemistry, 2012, 30, 1331–1334.

Yanying Zhou, Shihong Luo, Tingshuang Yi, Chunhuan Li, Qian Luo, Juan Hua, Yan Liu, Shenghong Li*. “Secondary metabolites from Glycine soja and their growth inhibitory effect against Spodoptera litura”, Journal of Agricultural and Food Chemistry, 2011, 59, 6004–6010.

Shihong Luo, Linhong Weng, Mingjin Xie, Xiaonian Li, Juan Hua, Xu Zhao, Shenghong Li*. “Defensive sesterterpenoids with unusual antipodal cyclopentenones from the leaves of Leucosceptrum canum”, Organic Letters, 2011, 13, 1864–1867.

Shihong Luo, Qian Luo, Xuemei Niu, Mingjin Xie, Xu Zhao, Bernd Schneider, Jonathan Gershenzon, Shenghong Li*. “Glandular trichomes of Leucosceptrum canum harbor defensive sesterterpenoids”, Angewandte Chemie International Edition, 2010, 49, 4471–4475.

Chunhuan Li, Xuemei Niu, Qian Luo, Mingjin Xie, Shihong Luo, Yanying Zhou and Shenghong Li*. “Novel polyesterified 3,4-seco-grayanane diterpenoids as antifeedants from Pieris formosa”, Organic Letters, 2010, 12, 2426–2429.

孙汉董主编,黎胜红副主编,《二萜化学》,69.6万字,化学工业出版社,北京,2012。

终审:药学院管理员
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