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中药化学方向

熊亮

   个人简介

熊亮,博士、博士后、研究员、硕士生导师、毕业于北京协和医学院&中国医学科学院药物研究所,现工作于成都中医药大学药学院、西南特色中药资源国家重点实验室;担任成都中医药大学西南特色药材创新药物成分研究所所长;入选四川省首届万人计划人才、四川省杰出青年基金,四川省中医药学术和技术带头人、四川省学术技术带头人后备人选、成都中医药大学首届青年英才;现任四川省食品药品监督管理局药品注册核查专家、四川省药品安全专家委员会专家、四川省科技专家库专家、国家自然科学基金评审专家、教育部学位论文评审专家、世界中联中药上市后再评价专业委员会常务理事、中国民族医药学会信息与大数据分会常务理事等。

近年来,专注于活血化瘀中药治疗心脑血管疾病和妇科疾病的研究,围绕益母草、川芎、姜黄、莪术、红花、山莨菪等活血化瘀药材,开展系统的物质基础及创新药物研究。共获得1200余个中药成分,其中新化合物350余个,新骨架化合物29个,发现了一系列具有显著活性的中药成分。主持国家自然科学基金面上项目、国家自然科学基金青年基金、霍英东基金、四川省杰出青年基金、中国博士后科学基金、四川省应用基础研究等项目14项,主研国家自然基金重大项目(排名第3)、国家自然基金重点项目(排名第2)、国家重大新药创制专项、国家中药标准化项目等重要课题。共发表学术论文120余篇,含SCI论文63篇,其中以第一作者或通讯作者发表SCI论文43篇,包括在本专业知名期刊Org. Lett.J. Nat. Prod.等发表多篇论文,单篇最高他引次数104次;出版专著7部,其中副主编3部,以副主编出版十三五规划教材《天然药物化学》;获得授权发明专利19项,含欧洲专利1项;获得2017年度四川省科技进步奖一等奖,2019年度中医药国际贡献奖-科技进步奖二等奖,2013年度华夏医学科技奖二等奖。

   代表性成果

1.      Yu Liu#; Fei Liu#; Ming-Ming Qiao; Li Guo; Ming-Hua Chen; Cheng Peng*; Liang Xiong*; Curcumanes A and B, Two Bicyclic Sesquiterpenoids with Significant Vasorelaxant Activity from Curcuma longa, Organic Letters, 2019, 21(4): 1197-1201.

2.      Liang Xiong; Qin-Mei Zhou; Yike Zou; Ming-Hua Chen; Li Guo; Guan-Ying Hu; Zhao-Hua Liu; Cheng Peng*; Leonuketal, a spiroketal diterpenoid from Leonurus japonicus, Organic Letters, 2015, 17(24): 6238-6241.

3.      Qin-Mei Zhou#; Ming-Hua Chen#; Xiao-Hong Li; Cheng Peng*; Da-Sheng Lin; Xiao-Nian Li; Yang He; Liang Xiong*; Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin, Journal of Natural Products, 2018, 81(9): 1919-1927.

4.      Fu Peng; Chun-Wang Meng; Qin-Mei Zhou; Jian-Ping Chen*; Liang Xiong*; Cytotoxic evaluation against breast cancer cells of isoliquiritigenin analogues from Spatholobus suberectus and their synthetic derivatives, Journal of Natural Products, 2016, 79(1): 248-251.

5.      Liang Xiong; Mei Zhu; Chenggeng Zhu; Sheng Lin; Yongchun Yang; Jiangong Shi*; Structure and bioassay of triterpenoids and steroids isolated from Sinocalamus affinis, Journal of Natural Products, 2012, 75(6): 1160-1166.

6.      Liang Xiong; Chenggeng Zhu*; Yanru Li; Ye Tian; Sheng Lin; Shaopeng Yuan; Jinfeng Hu; Qi Hou; Naihong Chen; Yongchun Yang; Jiangong Shi*; Lignans and neolignans from Sinocalamus affinis and their absolute configurations, Journal of Natural Products, 2011, 74(5): 1188-1200.

7.      Fei Liu#; Jin-Feng Chen#; Ming-Ming Qiao; Hao-Yu Zhao; Qin-Mei Zhou; Li Guo; Cheng Peng*; Liang Xiong*; Seven pairs of new enantiomeric sesquiterpenoids from Curcuma phaeocaulis, Bioorganic Chemistry, 2020, 99: 103820.

8.      Ming-Ming Qiao#; Fei Liu#; Yu Liu; Li Guo; Qin-Mei Zhou; Cheng Peng*; Liang Xiong*; Curcumane C and (±)-curcumane D, an unusual seco-cadinane sesquiterpenoid and a pair of unusual nor-bisabolane enantiomers with significant vasorelaxant activity from Curcuma longa, Bioorganic Chemistry, 2019, 92: 103275.

9.      Fei Liu#; Jin-Feng Chen#; Yue Wang; Li Guo; Qin-Mei Zhou; Cheng Peng*; Liang Xiong*; Cytotoxicity of lanostane-type triterpenoids and ergosteroids isolated from Omphalia lapidescens on MDA-MB-231 and HGC-27 cells, Biomedicine & Pharmacotherapy, 2019, 118: 109273.

10.  Lu-Lin Miao; Qin-Mei Zhou; Cheng Peng*; Zhao-Hua Liu; Liang Xiong*; Leonurus japonicus (Chinese motherwort), an excellent traditional medicine for obstetrical and gynecological diseases: A comprehensive overview, Biomedicine & Pharmacotherapy, 2019, 117: 109060.

11.  Zhong-Hui Pu; Cheng Peng*; Xiao-Fang Xie; Min Luo; Huan Zhu; Rui Feng; Liang Xiong*; Alkaloids from the rhizomes of Ligusticum striatum exert antimigraine effects through regulating 5-HT1B receptor and c-Jun, Journal of Ethnopharmacology, 2019, 237: 39-46.

12.  Hai-Guo Su; Qin-Mei Zhou; Li Guo; Yuan-Jin Huang; Cheng Peng*; Liang Xiong*; Lanostane triterpenoids from Ganoderma luteomarginatum and their cytotoxicity against four human cancer cell lines, Phytochemistry, 2018, 156: 89-95.

13.  Juan Liu; Cheng Peng*; Qin-Mei Zhou; Li Guo; Zhao-Hua Liu; Liang Xiong*; Alkaloids and flavonoid glycosides from the aerial parts of Leonurus japonicus and their opposite effects on uterine smooth muscle, Phytochemistry, 2018, 145: 128-136.

14.  Ya-Cong He; Cheng Peng*; Xiao-Fang Xie; Ming-Hua Chen; Xiao-Nian Li; Meng-Ting Li; Qin-Mei Zhou; Li Guo; Liang Xiong*; Penchinones A–D, two pairs of cis-trans isomers with rearranged neolignane carbon skeletons from Penthorum chinense, RSC Advances, 2015, 5(94): 76788-76794.

15.  Lu-Lin Miao#; Qin-Mei Zhou#; Cheng Peng*; Chun-Wang Meng; Xiao-Ya Wang; Liang Xiong*; Discrimination of the Geographical Origin of the Lateral Roots of Aconitum carmichaelii Using the Fingerprint, Multicomponent Quantification, and Chemometric Methods, Molecules, 2019, 24(22): 4124.

 

 


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