官方QQ
官方微信
手机版
您的位置:首页 >硕士生导师>中药化学方向>详细内容

中药化学方向

黄维

15563ac059dc4e068895cf3940a31e0e.Jpeg

黄维,医学博士/博士后,教授,博士研究生导师。四川省杰出青年资助计划,世界中医药学会联合会“中药上市后再评价专业委员会”委员,四川省第二届药品安全专家委员会委员秘书。

研究方向:中药活性成分机制及构效关系研究;结合中药多成分、多靶点协同作用特点,融合生物信息学、网络药理学、系统毒理学、手性合成、计算化学等多学科手段,研究中药药效物质作用机制及构效关系。

目前作为负责人,主持国家自然科学基金面上项目3项、国家自然科学基金青年基金、四川省重点研发项目、四川省杰出青年基金、中国博士后科学基金特别资助项目、中国博士后科学基金面上项目(一等)、教育部博士点基金、四川省科技厅基础项目等课题;相关成果发表在Chemical Communications; Organic Chemistry Frontiers; Acta Pharmaceutica Sinica B; Advanced Synthesis & Catalysis等国内外学术期刊上,共计收录八十余篇,其中以第一作者或通讯作者发表SCI论文35篇;获得国家授权发明专利7项;参编规划教材6部,包括“十三五”规划教材《药物化学》、“十三五”规划教材《天然药物化学》。

获四川省科技进步一等奖。入选首届成都中医药大学“天府学者”学术荣誉体系:青年英才;入选第十三批四川省学术和技术带头人后备人选;指导学生参加教育部高等学校第九届国际大学生“药苑论坛”:获创新成果奖、优秀墙报奖;指导的硕士研究生多次获得国家奖学金和学业奖学金。

联系方式:huangwei@cdutcm.edu.cn 

主持基金项目:

1.国家自然科学基金面上项目,钩藤吲哚生物碱诱导线粒体自噬治疗PD的分子网络机制和立体异构效应研究,2021/01/-2024/12,55万元,负责人

2.国家自然科学基金面上项目,以配位化学关联手性结构特征探究中药熟地黄通过自噬-溶酶体途径治疗帕金森病的物质基础,2018/01-2021/12,55万元,负责人

3.国家自然科学基金面上项目,融合多层次化学结构特征研究钩吻中吲哚生物碱抗乳腺癌的构效关系和作用机制,2016/01-2019/12,57万元,负责人

4.国家自然科学基金青年项目,基于多靶标网络调控研究青黛治疗慢粒白血病的药效物质基础和作用机制,2014/01-2016/12,23万元,负责人

5.四川省重点研发项目,中药调控细胞程序性死亡的活性物质库构建和成药性评价,2021/04-2023/03,100万元,负责人

6.成都中医药大学一流学科项目,硫代二酮哌嗪类吲哚生物碱诱导肿瘤细胞自噬性死亡的分子网络机制研究,2018/01-2022/12,100万元,负责人

代表性成果:

1.Cui Ye, Nan Zhang, Qian Zhao, Xin Xie, Xiang Li, Hong-Ping Zhu, Cheng Peng*, Wei Huang*. Evodiamine alleviates lipopolysaccharide-induced pulmonary inflammation and fibrosis by activating apelin pathway. Phytotherapy Research. 2021, 1-12.

2.Shuai-Jiang Liu, Qing Mao, Ya-Jun Zhong, Jing Xue, Ben-Hong Chen, Qian Zhao*, Wei Huang*. Highly diastereoselective assembly of isoxazole and trifluoromethyl containing spiro[pyrrolidin-oxindoles] from N-2,2,2-trifluoroethylsubstituted isatin imines and styrylisoxazoles. Tetrahedron Letters, 2020,doi.org/10.1016/j.tetlet.2020.152687.

3.Hai-Jun Leng+, Yu-Ting Wang+, Xiang-Hong He+, Hou-Lin Xia,* Peng-Shuai Xu,Peng Xiang, Qing-Qing He, Gu Zhan,* Wei Huang*. Design and Efficient Synthesis of RalA Inhibitors Containing the Dihydro-α-carboline Scaffold. ChemMedChem, 2020, 15, 1-10.

4.Chen Fei-Yu, Li Xiang, Zhu Hong-Ping, Huang Wei*. Regulation of the Ras-Related Signaling Pathway by Small Molecules Containing an Indole Core Scaffold: a Potential Antitumor Therapy. Frontiers in Pharmacology, 2020, 11, 280.  

5.Zhao Qian, Zhu Hong-Ping, Xie Xin, Mao Qing, Liu Yan-Qing, He Xiang-Hong, Peng Cheng, Jiang Qing-Lin*, Huang Wei*. Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways. International Journal of Molecular Science, 2020, 21, 1845.  

6.Ren Wen, Zhao Qian, Yu Meng, Guo Li, Chang Hongmei, Jiang Xian, Luo Yonfu, Huang Wei*, He Gu*. Design and synthesis of novel spirooxindole–indenoquinoxaline derivatives as novel tryptophanyl-tRNA synthetase inhibitors. Molecular Diversity, 2019, 10.1007/s11030-019-10011-2.  

7.Chen Can, Jiang Li, Zhang Min, Pan Xiaoli, Peng Cheng, Huang Wei *, Jiang Qinglin*. Isodunnianol alleviates doxorubicin-induced myocardial injury by activating protective autophagy. Food Function, 2019, 10, 2651-2657.

8.Ji Yan-Li, He Xiang-Hong, Peng Cheng *, Huang Wei*. Recent advances in the synthesis of C2-spiropseudoindoxyls. Organic & Biomolecular Chemistry, 2019, 17, 2850-2864.  

9.Tang Xue, Zhu Hong-Ping, Zhou Jin, Chen Yang, Pan Xiao-Li, Guo Li, Li Jun-Long, Peng Cheng*, HuangWei*. Highly diastereoselective synthesis of cyclopropane-fused spiro-pseudoindoxyl derivatives through [2 + 1] annulation of 2-ylideneoxindoles and sulfonium bromides. Organic & Biomolecular Chemistry, 2018, 16, 8169-8174.  

10.Li Xiang, Liu Yan-Qing, Kang Jing-Wen, Chen Fei-Yu, He Xi-Guo, Yuan Shan-Shan, Guo Li, Cheng Peng *, Huang Wei *. Synthesis of Vinylcyclopropane-Fused Pyrazolone Derivatives by Sulfur Ylide-Initiated 1,6-Michael Addition-Cyclization Reactions. European Journal of Organic Chemistry, 2018, 4723-4730.  

11.Liu Yanqing, Ouyang Liang, Tan Ying, Tang Xue, Kang Jingwen, Wang Chunting, Zhu Yaning, Peng Cheng*, Huang Wei*. One-Pot Two-Step Organocatalytic Asymmetric Synthesis of Spirocyclic Piperidones via Wolff Rearrangement–Amidation-Michael- Hemiaminalization Sequence. Catalysts 2017, 7, 46.      

12.Huang Wei, Cai Lulu, Chen Can, Xie Xin, Zhao Qiong*, Zhao Xing, Zhou Hong-yun, Han Bo, Peng Cheng*. Computational analysis of spiro-oxindole inhibitors of the MDM2-p53 interaction: insights and selection of novel inhibitors. Journal of Biomolecular Structure & Dynamics, 2016, 34, 341-351.  

13.Wang Biao, Leng Hai-Jun, Yang Xue-Yuan, Han Bo, Rao Chao-Long, Liu Li, Peng Cheng*, Huang Wei*. Efficient synthesis of tetrahydronaphthalene- or isochroman-fused spirooxindoles using tandem reactions. Rsc Advances, 2015, 5, 88272-88276.  

14.Zhao Qian, Han Bo, Wang Biao, Leng Hai-Jun, Peng Cheng*, Huang Wei*. Synthesis of functionalized gamma-lactones via a three-component cascade reaction catalyzed by consecutive N-heterocyclic carbene systems. Rsc Advances, 2015, 5, 26972-26976.  

15.Li Xiang, Yang Lei, Peng Cheng*, Xie Xin, Leng Hai-Jun, Wang Biao, Tang Zheng-Wei, He Gu, Ouyang Liang, Huang Wei*, Han Bo*. Organocatalytic tandem Morita-Baylis-Hillman-Michael reaction for asymmetric synthesis of a drug-like oxa-spirocyclic indanone scaffold. Chemical Communications, 2013, 49, 8692-8694.  

终审:药学院管理员
【打印正文】