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中药化学方向

刘燕

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个人简介:

      刘燕,女,理学博士,入选中组部“西部之光”西部青年学者A类、中国科学院青年创新促进会会员。

研究方向:

     药用植物活性天然产物的形成机制研究:主要运用分子生物学、植物化学、生物信息学、合成生物学等多学科交叉技术,开展药用植物中结构新颖活性显著天然产物的生物合成研究,鉴定关键酶的功能并揭示其催化机制,发现天然产物的生物功能,解析活性天然产物的形成机制。在此基础上开展重要或低含量活性天然产物的合成生物学和组合生物合成研究。

主持科研项目:

(1)     NSFC-云南联合基金重点项目(No. U1902214),2020.01-2023.12,267.6万元

(2)     国家自然科学基金面上项目(No. 31770340),2018.01-2021.12,71万,主持

(3)     国家自然科学基金面上项目(No. 31470395),2015.01-2018.12,80万,主持

(4)     国家自然科学基金青年基金项目(No. 31100222),2012.01-2014.12,22万,主持

(5)     云南省应用基础研究计划项目重点项目(No. 2018FA017),2018.06-2021.05,50万,主持

(6)     中国科学院青年创新促进会专项基金,2016.01-2019.12,80万,主持

(7)     中国科学院西部之光——西部青年学者A类专项基金,2019.01-2021.12,50万,主持

(8)     云南省“万人计划”青年拔尖人才专项基金,2019.01-2023.12,50万,主持

 

代表性论文及专利 (#为第一作者,*为通讯作者):

(1)   Chen, Yue-Gui#; Li, De-Sen#; Ling, Yi#; Liu, Yan-Chun; Zuo, Zhi-Li; Gan, Li-She; Luo, Shi-Hong; Hua, Juan; Chen, Ding-Yuan; Xu, Fan; Li, Man; Guo, Kai; Liu, Yan*; Gershenzon, Jonathan; Li, Sheng-Hong*. A cryptic plant terpene cyclase producing unconventional 18- and 14-membered macrocyclic C25 and C20 terpenoids with immunosuppressive activity. Angewandte Chemie-International Edition, 2021, 60: 25468-25476.

(2)   Liu, Yan#; Luo, Shi-Hong#; Hua, Juan; Li, De-Sen; Ling, Yi; Luo, Qian; Li, Sheng-Hong*. Characterization of defensive cadinenes and a novel sesquiterpene synthase responsible for their biosynthesis from the invasive Eupatorium adenophorum, New Phytologist, 2021, 229: 1740-1754.

(3)   Guo, Kai#, Liu, Yan#; Li, Sheng-Hong*.The untapped potential of plant sesterterpenoids: chemistry, biological activities and biosynthesis. Natural Product Reports, 2021, DOI: 10.1039/d1np00021g.

(4)   Li, De-Sen; Hua, Juan; Luo, Shi-Hong; Liu, Yan-Chun; Chen, Yue-Gui; Ling, Yi; Guo, Kai; Liu, Yan*, Li, Sheng-Hong*. An extremely promiscuous terpenoid synthase from the Lamiaceae plant Colquhounia coccinea var. mollis catalyzes the formation of sester-/di-/sesqui-/mono-terpenoids. Plant Communications, 2021, 2: 100233. (Cover Article, Cell Press)

(5)   Wang, Ying#; Liu, Yan-Chun; Li, Wen-Yuan; Guo, Kai; Liu, Yan*; Li, Sheng-Hong*. Antifeedant, cytotoxic, and anti-inflammatory neo-clerodane diterpenoids in the peltate glandular trichomes and fresh leaves of Ajuga forrestii, Phytochemistry, 2021, 186: 112731.

(6)   Gao, Jian-Xiong#; Chen, Yue-Gui; Li, De-Sen; Lin, Liang; Liu, Yan*; Li, Sheng-Hong*. Cloning and functional characterization of a squalene synthase from Paris polyphylla var. yunnanensis. Chemistry & Biodiversity, 2021, 18: e2100342.

(7)   Tang, Ting#; Li, Chun-Huan#; Li, De-Sen; Jing, Shu-Xi; Hua, Juan; Luo, Shi-Hong; Liu, Yan*; Li, Sheng-Hong*. Peltate glandular trichomes of Colquhounia vestita harbor diterpenoid acids that contribute to plant adaptation to UV radiation and cold stresses, Phytochemistry, 2020, 172: 112285.

(8)   Luo, Liu-Qiong#; Chen, Yue-Gui; Li, De-Sen; Liu, Yan*; Li, Sheng-Hong*. Production of the inaccessible sesquiterpene (−) of the inaccessible sesquiterpene (−)-5-epieremophilene by metabolically epieremophilene by metabolically engineered Escherichia coli, Chemistry & Biodiversity, 2020, 17: e2000219.

(9)   Liu, Yan#; Jing, Shu-Xi#; Luo, Shi-Hong; Li, Sheng-Hong*. Non-volatile natural products in plant glandular trichomes: chemistry, biological activities and biosynthesis, Natural Product Reports, 2019, 36: 626-665.

(10) Luo, Fei#; Ling, Yi; Li, De-Sen; Tang, Ting; Liu, Yan-Chun; Liu, Yan*; Li, Sheng-Hong*. Characterization of a sesquiterpene cyclase from the glandular trichomes of Leucosceptrum canum for sole production of cedrol in Escherichia coli and Nicotiana benthamiana, Phytochemistry, 2019, 162: 121-128.

(11) Ling, Yi#; Teng, Lin-Lin; Hua, Juan; Li, De-Sen; Luo, Shi-Hong; Liu, Yan-Chun; Liu, Yan*; Li, Sheng-Hong*. Leucosceptroid B from glandular trichomes of Leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis, Chinese Journal of Natural Medicines, 2019, 17: 0892-0899.

(12) Xiao, Chao-Jiang#; Liu, Yan-Chun; Luo, Shi-Hong; Hua, Juan; Liu, Yan*; Li, Sheng-Hong*. Localisation of two bioactive labdane diterpenoids in the peltate glandular trichomes of Leonurus japonicus by laser microdissection coupled with UPLC-MS/MS, Phytochemical Analysis, 2017, 28: 404-409.

(13) Tan, Yan-Yun#; Li, De-Sen; Hua, Juan; Luo, Shi-Hong; Liu, Yan*; Li, Sheng-Hong*. Localization of a defensive volatile 4-hydroxy-4-methylpentan-2-one in the capitate glandular trichomes of Oenothera glazioviana, Plant Diversity, 2017, 39: 154-159.

(14) Liu, Yan#; Luo, Shi-Hong; Schmidt, Axel; Wang, Guo-Dong; Sun, Gui-Ling; Grant, Marcus; Kuang, Ce; Yang, Min-Jie; Jing, Shu-Xi; Li, Chun-Huan; Schneider, Bernd; Gershenzon, Jonathan; Li, Sheng-Hong*. A geranylfarnesyl diphosphate synthase provides the precursor for sesterterpenoid (C25) formation in the glandular trichomes of the mint species Leucosceptrum canum, Plant Cell, 2016, 28: 804-822. (Cover article)

(15) Zhang, Cai-Guo#; Liu, Yan*. Targeting cancer with sesterterpenoids: the new potential antitumor drugs, Journal of Natural Medicines, 2015, 69: 255-266.

(16) Li, Chun-Huan#; Liu, Yan#; Hua, Juan; Luo, Shi-Hong; Li, Sheng-Hong*. Peltate glandular trichomes of Colquhounia seguinii harbor new defensive clerodane diterpenoids, Journal of Integrative Plant Biology, 2014, 56: 928-940.

(17) 黎胜红,郭凯,刘艳春,刘燕,“二倍半萜化合物及其制备方法和在制备抗炎药物和免疫抑制药物中的应用”,专利号:202010181323.0,授权日期:2021年 2 月 24 日

(18) 黎胜红,刘燕,陈月桂,凌伊,刘艳春,“双功能二倍半萜/二萜合酶LcTPS2、编码基因及其产物和应用”,公开号:202110479022.0,公开日期:2021年4月30日

(19) 黎胜红,刘燕,罗菲,刘艳春,“雪松醇合酶 Lc-CedS 编码基因及其应用”,公开号:201910108138.6,公开日期: 2019 年 2 月 2 日

(20) 黎胜红,景树溪,刘燕,刘艳春,“火把花烷二倍半萜化合物及其制备方法、药物组合物及应用和火把花总提物的应用”,公开号:202110276052.1,公开日期:2021年3月15日

 


终审:药学院管理员
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