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中药药理方向

谢晓芳

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个人简介

谢晓芳,博士,副研究员,硕士研究生导师,药学院科研中心教师;为世界中医药学会联合会李时珍医药研究与应用专业委员会常务理事、世界中医药学会联合会道地药材多维评价专业委员会理事,四川省环境诱变剂学会理事。研究方向为中药药理学。该近年先后承担四川省科技厅、四川省中医药管理局等6个项目,参加国家自然科学基金重大、重点项目、国家科技支撑计划项目、国家“973”计划等项目20余项,参研完成中药复方新药品种7个,获四川省科技进步奖一等奖1项(排名第9)、华夏医学科技进步二等奖1项(排名第4),开发表学术论文120余篇,其中第一作者或通讯作者发表学术论文24篇,,参编著作和教材8部,参研完成中药复方新药品种7个。对代表性川产道地药材开展有效性和安全性研究,在中药药效和毒性研究方面积累丰富经验。

代表性成果

1.Yan Chen, Jiayu Wen, Zixin Deng, Xiaoqi Pan, Xiaofang Xie*, Cheng Peng*. Effective utilization of food wastes: bioactivity of grape seed extraction and its application in food industry[J]. Journal of Funtional Foods, 2020. (http://doi.org/10.1016/j.jff.2020.104113)

2. Li Mengting#, Xie Xiaofang#, Chen haimei, Xiong Qiuyun, Tong Rongsheng, Peng Cheng*, Peng Fu*. Aconitine induces cardiotoxicity through regulation of calcium signaling pathway in zebrafish embryos and in H9c2 cells[J]. J Appl Toxicol., 2020, 40(6): 780-793.

3. Peng Fu, Xie Xiaofang, Peng Cheng*. Chinese Herbal Medicine-Based Cancer Therapy: Novel Anticancer Agents Targeting MicroRNAs to Regulate Tumor Growth and Metastasis[J]. The American Journal of Chinese Medicine, 2019, 47(8):1711-1735.

4.Li Mengting, He Yulin, Peng Cheng*, Xie Xiaofang*, Hu Guanying.  Erianin inhibits human cervical cancer cell through regulation of tumor protein p53 via the extracellular signal-regulated kinase signaling pathway[J]. Oncology letters, 2018, 16(4): 5006-5012.

5. Hu Guanying, Peng Cheng*, Xie Xiaofang*, Xiong Liang, Zhang Sanyin, Cao Xiaoyu, Patchouli Alcohol Isolated from Pogostemon Cablin Mediates Endothelium-Independent Vasorelaxation by Blockade of Ca2+ Channels in Rat Isolated Thoracic Aorta[J]. Journal of Ethnopharmacology, 2018, 220(28): 1880196.

6. Chen Dandan, Peng Cheng*, Xie Xiaofang*, Chen Qiuling, Liu Han, Zhang Shiyang, Wan Feng, Ao Hui. Low Dose of Anisodine Hydrobromide Induced Neuroprotective Effects in Chronic Cerebral Hypoperfusion Rats[J]. CNS & Neurological Disorders-Drug Targets, 2017, 16(10): 1111-1119.

7. Tan Yuzhu, Yan Yong, Dong Yanhong, Wang Rujing,Li Hongxiang, Guo Dale, Zhang Shijin, Dong Xiaoping*, Xie Xiaofang*. A new secoiridoid glycoside and a new sesquiterpenoid glycoside from Valeriana jatamansi with neuroprotective activity[J]. Phytochemistry Letters, 2016, 17: 177-180.

8. Peng Fu, Xiong Liang, Xie Xiaofang, Tang Hailin, Huang ruizhen*, Peng Cheng*. Isoliquiritigenin Derivative Regulates miR-374a/BAX Axis to Suppress Triple-Negative Breast Cancer Tumorigenesis and Development[J]. Frontiers in Pharmacology, 2020. (DOI: 10.3389/fphar.2020.00378)

9. PanXiaoqi, Zhou Jie, Chen Yan, Xie Xiaofang, Rao Chaolong, Liang Jie,Zhang Ying, Peng Cheng*. Classification, hepatotoxic mechanisms, and targets of the risk ingredients in traditional Chinese medicine-induced liver injury[J]. Toxicology letters, 2020, 323: 48-56.

10. Zhong-Hui Pu, Cheng Peng*, Xiao-Fang Xie, Min Luoa, Huan Zhu, Rui Feng, Liang Xiong*. Alkaloids from the rhizomes of Ligusticum striatum exert antimigraine effects through regulating 5-HT1B receptor and c-Jun[J]. Journal of Ethnopharmacology, 2019, 237: 39-46.

11.Zhong-Hui Pu, Juan Liu, Cheng Peng*, Min Luo, Qin-Mei Zhou, XiaoFang Xie, Ming-Hua Chen, Liang Xiong*. Nucleoside alkaloids with anti-platelet aggregation activity from the rhizomes of Ligusticum striatum[J]. Natural Product Research, 2019, 33(10): 1399-1405.

12. 唐欣, 谢晓芳, 王文林, 饶朝龙, 彭成*.附子对妊娠虚寒腹痛模型大鼠的毒效研究[J]. 中药药理与临床, 2019, 35(3): 101−105.

13.陈海媚,陈秋伶,李梦婷,谢晓芳#,彭成#.附子不同组分抗急性心力衰竭大鼠的实验研究[J].天然产物研究与开发, 2019, 31 (3):408-414

14. 谢晓芳,陈俊仁,李刚敏,彭成*. 益母草对子宫的药理作用研究进展[J].世界中医药,2020, 15(9): 1263-1266.

15.谢晓芳,陈冠儒,彭成.益母草注射液防治产后出血的临床应用研究进展[J].世界中医药,2020,15(9):1253-1257.

终审:药学院管理员
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