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中药药理方向

王平

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个人简介

王平,硕士、副教授。本科和硕士于成都中医药大学中药学和药理学专业学习。2004年留校进入药理教研室工作至今。 主要研究方向为计算生物学模型识别清热药中化合物药效或毒理的反应程度,主要使用分子动力学、分子模拟、药效学-药动学联合模型、组学的图算法等工具开展相应工作。目前研究兴趣在于寻找和使用识别双分子组合药效或毒效改变趋势的研究方法,以解释相关配伍机理。在国家自然科学青年基金等项目支持下,近年来初步实现了对单一化合物的相关模型构建,发表相关研究论文41篇。

代表性成果

1.Li Xiang,Youdong Xu,Yan Zhang,Xianli Meng,Ping Wang*. Virtual screening studies of Chinese medicine Coptidis Rhizoma as alpha7 nicotinic acetylcholine receptor agonists for treatment of Alzheimer’s disease[J]. Journal of Molecular Structure,2015,1086.  

2.Li Xiang, Ying-Fan Hu,Jia-Si Wu, Li Wang, Wen-Ge Huang, Chen-Si Xu, Xian-Li Meng*, Ping Wang*. Semi-Mechanism-Based Pharmacodynamic Model for the Anti-Inflammatory Effect of Baicalein in LPS-Stimulated RAW264.7 Macrophages. Front Pharmacol. 2018 Jul 18;9:793. doi: 10.3389/fphar.2018.00793. eCollection 2018.

3.Yingfan Hu, Li Wang, Li Xiang, Jiasi Wu, Wen’ge Huang, Chensi Xu, Xianli Meng, Ping Wang*. Pharmacokinetic-Pharmacodynamic Modeling for Coptisine Challenge of Inflammation in LPS-Stimulated Rats. Sci Rep. 2019;9(1):1450. Published 2019 Feb 5. doi:10.1038/s41598-018-38164-4

4.Liang Zou, Yan Zhang, Wei Li, Jinming Zhang, Dan Wang, Jia Fu*, Ping Wang*.Comparison of Chemical Profiles, Anti-Inflammatory Activity, and UPLC-Q-TOF/MS-Based Metabolomics in Endotoxic Fever Rats between Synthetic Borneol and Natural Borneol. Molecules. 2017;22(9):1446. Published 2017 Aug 31. doi:10.3390/molecules22091446

5.Wen'ge Huang, Yingzhuo Yang, Wen Wen, Yu Luo, Jiasi Wu, Li Xiang, Yinfan Hu, Shijun Xu, Simin Chen*, Ping Wang*. Vanillin enhances the  passive transport rate and absorption of drugs with moderate oral bioavailability in vitro and in vivo by affecting the membrane structure. Food Funct. 2020;11(1):700-710. doi:10.1039/c9fo02846c

6.Yu Luo, Qing Jiang, Zhengwen Zhu, Haseeb Sattar, Jiasi Wu, Wenge  Huang, Siyu Su, Yusheng Liang, Ping Wang *, Xianli Meng*. Phosphoproteomics and Proteomics Reveal Metabolism as a Key Node in LPS-Induced Acute Inflammation in RAW264.7 [published online ahead of print, 2020 Jun 2]. Inflammation. 2020;10.1007/s10753-020-01240-x. doi:10.1007/s10753-020-01240-x

7.蒋晴,罗煜,朱正文,梁雨生,吴嘉思,苏丝雨,曾勇,孟宪丽,王平*.基于中效方程的黄芩苷与小檗碱抗炎协同作用研究[J].中国药理学通报,2020,36(03):443-444.

8.王丽,胡樱凡,童东,左芳,魏志成,孟宪丽,王平*.黄连碱对内毒素发热大鼠解热作用的PK-PD研究[J].中国药理学通报,2017,33(04):552-556.

9.徐佑东,张艳,孟宪丽,曾勇,王平*.基于反向对接法的黄连碱抗炎机制分子模拟研究[J].中药与临床,2016,7(02):56-60.

10.于宜平,张艳,李红,王平*,孟宪丽,陈小睿,曾勇. 黄芩苷对角叉菜胶致热大鼠解热作用的PK-PD模型研究[J].中草药,2014,45(04):527-531.

11.李红,张艳,于宜平,王平*,李帆帆,孟宪丽. 大黄解热作用与降低血浆一氧化氮作用的PK-PD研究[J].中国中药杂志,2013,38(08):1231-1236.

12.Boyang Hu, Hai Zhang, Xianli Meng, Fei Wang*, Ping Wang*. Aloe-emodin from rhubarb (Rheum rhabarbarum) inhibits lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages. J Ethnopharmacol. 2014;153(3):846-853. doi:10.1016/j.jep.2014.03.059

13.Siyu Su, Jiasi Wu, Yue Gao, Yu Luo, Dong Yang, Ping Wang*. The pharmacological properties of chrysophanol, the recent advances. Biomed Pharmacother. 2020;125:110002. doi:10.1016/j.biopha.2020.110002

14.Shi-Yu Chen, Yue Gao, Jia-Yi Sun, Xian-Li Meng, Dong Yang, Lin-Hong Fan, Li Xiang*, Ping Wang*. Role in Reducing β-Amyloid,  Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer's Disease. Front Pharmacol. 2020;11:497. Published 2020 Apr 22. doi:10.3389/fphar.2020.00497

15.Jiasi Wu, Yingfan Hu, Li Xiang, Sheng Li, Yi Yuan, Xiaomei Chen, Yan Zhang, Wenge Huang, Xianli Meng*, Ping Wang*. San-Huang-Xie-Xin-Tang Constituents Exert Drug-Drug Interaction of Mutual Reinforcement at Both Pharmacodynamics and Pharmacokinetic Level: A Review. Front Pharmacol. 2016;7:448. Published 2016 Nov 28. doi:10.3389/fphar.2016.00448

终审:药学院管理员
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