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中药制剂与炮制方向

李小芳

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个人简介

李小芳,博士、教授、博士研究生导师;药学院中药炮制与制剂系主任。成都中医药大学优势特色学科药剂学学科带头人

为国家中医药考试命审题专家、国家自然科学基金委同行评议专家、国家卫计委医药卫生科技发展中心科研项目评审专家、教育部学位中心评审专家、四川省院士(专家)工作站专家、四川省科技计划项目评审专家、四川省科技成果奖励评审专家、四川省药品注册现场核查专家、四川省基本医疗保险专家、北京市自然科学基金评审专家、河北省科技计划项目评审专家。尚任中华中医药学会中药制剂分会常务委员、世界中医药学会联合会道地药材多维评价专业委员会常务理事、成都市药学会第八届药剂专业委员会副主任委员等学术职务。

研究方向:中药新制剂、新技术、新剂型及新辅料研究。

长于中药新药研究、中药制剂关键技术及中药结肠定位新制剂等领域的研究。作为负责人和主研人员承担了国家“十五”科技攻关项目、国家自然科学基金项目、科技部863项目、国家“十一五”科技支撑计划以及部省级、厅局级课题共30余项;作为主研参与并取得具有代表性的科研成果有藿香正气口服液的研制、太极通天液的研制,均获生产批文,已上市。“藿香正气口服液的制备方法”于1997年获中国专利发明金奖,为国内首次获此殊荣的中药产品。

公开发表学术论文180余篇,其中SCI论文20余篇;主编、副主编《中药药剂学》、《中药药剂学实验》、《药剂学》、《中药提取工艺学》、《中药制药工艺学》等规划教材9部。以第一发明人申请国家发明专利12项,其中已授权6项;获四川省及成都市科技进步奖5项。

已为国家培养硕、博士研究生80余名。

代表性成果

1. Jiawen Song, Jiaying Long, Long Xie, Qiang Sun, Linlin Zhang, Huijuan Chen, Mao Deng, Xiaofang Li,Solubilization and changes of physicochemical properties of baicalin by nano sponge, and toxicity of zebrafish liver,Journal of Drug Delivery Science and Technology,Volume 60,2020,102003

2.Jiaying Long, Jiawen Song, Xumin Zhang, Mao Deng, Long Xie, Linlin Zhang, Xiaofang Li. Tea saponins as natural stabilizers for the production of hesperidin nanosuspensions [J]. International Journal of Pharmaceutics, 583, 119406.

3.Chengying Shen, Junjun Zhu, Jiawen Song, Jing Wang, Baode Shen, Hailong Yuan, Xiaofang Li. Formulation of Pluronic F127/TPGS Mixed Micelles toImprove the Oral Absorption of Glycyrrhizic Acid. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY.2020,46(7):1100-1107.

4.张琳琳,李小芳,谢龙,宋佳文,廖艳梅,仲粒.星点设计-效应面法优化基于甘草酸的葛根素纳米乳及其体外释放研究[J].中草药,2020,51(12):3180-3186.

5. Deng, M(Deng, Mao);Xie, L(Xie, Long);Zhong, L(Zhong, Li);Liao, YM(Liao, Yanmei);Liu, LN(Liu, Luona); Li, XF(Li, Xiaofang). Imperatorin: A review of its pharmacology, toxicity and pharmacokinetics. Eur J Pharmacol, 2020. 879: p. 173124.

6. Xie,QX(Xie, Qingxuan);Zhang, LL(Zhang, Linlin); Xie,L (Xie, Long); Zheng,Y (Zheng, Yu); Liu,K (Liu, Kai); Tang, HL (Tang, Hailong); Liao,YM(Liao, Yanmei); Li,XF (Li,Xiaofang). Z-ligustilide: A review of its pharmacokinetics and pharmacology[J]. Phytotherapy Research, 2020(4).

7. Yanmei Liao, Li Zhong, Luona Liu,Long Xie,Hailong Tang,Linlin Zhang,Xiaofang Li. Comparison of surfactants at solubilizing,forming and stabilizing nanoemulsion of hesperidin. Journal of food engineering.281(2020).

8.唐海龙,李小芳,龙家英,邓茂,谢龙,廖艳梅.以甘草酸为稳定剂制备水飞蓟素纳米混悬剂及稳定机制研究[J].中草药,2020,51(04):971-977.

9.Ren, GL (Ren, Guilin); Zhong, Y (Zhong, Yu); Ke, G (Ke, Gang); Liu, XL (Liu, Xiaoli); Li, HT (Li, Huiting); Li, XF (Li, Xiaofang); Zheng, Q (Zheng, Qin); Yang, M (Yang, Ming). The Mechanism of Compound Anshen Essential Oil in the Treatment of Insomnia Was Examined by Network Pharmacology. Evidence -Based Complementary and Alternative Medicine 2019/9241403

10.Song, JW (Song, Jiawen); Luo, J (Luo, Jia); Ma, ZB (Ma, Zubing); Sun, Q (Sun, Qiang); Wu, CJ (Wu, Chunjie); Li, XF (Li, Xiaofang). Quality and Authenticity Control of Functional Red Yeast RiceA Review. Molecules 2019,24(10):944.

11.Long, JY (Long, Jiaying); Song, JW (Song, Jiawen); Zhong, L (Zhong, Li); Liao, YM (Liao, Yanmei); Liu, LN (Liu, Luona); Li, XF (Li, Xiaofang). Palmatine: A review of its pharmacology, toxicity and pharmacokinetics. Biochimie 162 (2019):176–184.

12.Xie, L (Xie, Long); Tang, HL (Tang, Hailong); Song, JW (Song, Jiawen); Long, JY (Long, Jiaying); Zhang, LL (Zhang, Linlin); Li, XF (Li, Xiaofang). Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics. Journal of Pharmacy and Pharmacology 2019,71(9):1475–1487.

13.Zhao, TT (Zhao, Tiantian); Tang, HL (Tang, Hailong); Xie, L (Xie, Long); Zheng, Y (Zheng, Yu); Ma, ZB (Ma, Zubing); Sun, Q (Sun, Qiang); Li, XF (Li, Xiaofang). Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology. Journal of Pharmacy and Pharmacology 2019,71(9):1353–1369.

14.Yu Zheng, Lan Bai, Yanping Zhou, Rongsheng Tong, Minghui Zeng, Xiaofang Li, Jianyou Shi. Polysaccharides from Chinese herbal medicine for anti-diabetes recent advances. International Journal of Biological Macromolecules, 121 (2019) 1240–1253.

15.Chengli Ling, Jianming Liang, Chun Zhang, Ruixiang Li, Qianqian Mou, Jin Qin, Xiaofang Li, Jianxin Wang. Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury. Molecules 2018, 23(3):564.

终审:药学院管理员
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