1、个人简介

詹固博士，成都中医药大学高层次引进人才，特聘副教授，四川省特聘专家。2007-2016年于四川大学华西药学院学习并获得理学博士学位。同年赴美国纽约州立大学进行博士后研究，合作导师为张强教授，研究多肽的选择性化学合成。随后加入日本国立理化学研究所进行博士后研究，师从著名化学家侯召民教授。相关科研成果发表在Chem. Soc. Rev., Angew. Chem. Int. Ed., J. Am. Chem. Soc., Chem. Sci., Acs Catal.等国际顶级学术期刊上，并获得了“2018年日本国立理化学研究所研究奖励奖”、“2019年日本国立理化学研究所理事长感谢状”、“2019年英国皇家化学会OBC壁报奖”等个人奖项。目前的主要研究方向为中药相关手性化合物的催化合成、创新药物研发以及不对称催化新方法开发，任Frontiers in catalysis杂志副主编、Frontiers in chemistry杂志客座编辑、泰国中医药杂志编委。2019年底加入成都中医药大学药学院以来，已获“国家自然科学基金青年项目”、“四川省科技厅应用基础研究项目”、“成都中医药大学引进人才科研启动项目”等资助。

二、个人代表性成果

[1] G. Zhan⁺, W. Du⁺, Y.C. Chen, Switchable divergent asymmetric synthesis via organocatalysis, Chem. Soc. Rev., 46 (2017) 1675-1692. (中科院一区，IF:60.615)

[2] R. Qin, F.M. You, Q. Zhao, X. Xie, C. Peng, G. Zhan*, B. Han*, Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets, J. Hematol Oncol., 15 (2022) 133. (中科院一区，IF:23.168)

[3] G. Zhan, H.L. Teng, Y. Luo, S.J. Lou, M. Nishiura, Z.M. Hou*, Enantioselective Construction of Silicon-Stereogenic Silanes by Scandium-Catalyzed Intermolecular Alkene Hydrosilylation, Angew. Chem. Int. Ed., 57 (2018) 12342-12346. (中科院一区，IF:16.823)

[4] G. Zhan, M.L. Shi, Q. He, W.J. Lin, Q. Ouyang, W. Du, Y.C. Chen*, Catalyst-Controlled Switch in Chemo- and Diastereoselectivities: Annulations of Morita-Baylis-Hillman Carbonates from Isatins, Angew. Chem. Int. Ed., 55 (2016) 2147-2151. (中科院一区，IF:16.823)

[5] Y.H. Ma, S.J. Lou, G. Luo, Y. Luo, G. Zhan, M. Nishiura, Y. Luo, Z.M. Hou*, B(C6F5)3/Amine-Catalyzed C(sp)-H Silylation of Terminal Alkynes with Hydrosilanes: Experimental and Theoretical Studies, Angew. Chem. Int. Ed., 57 (2018) 15222-15226. (中科院一区，IF:16.823)

[6] X.F. Cong, G. Zhan, Z.B. Mo, M. Nishiura, Z.M. Hou*, Diastereodivergent [3+2] Annulation of Aromatic Aldimines with Alkenes via C-H Activation by Half-Sandwich Rare-Earth Catalysts, J. Am. Chem. Soc., 142 (2020) 5531-5537. (中科院一区，IF:16.383)

[7] H.L. Teng, Y.H. Ma, G. Zhan, M. Nishiura, Z.M. Hou*, Asymmetric C(sp)-H Addition of Terminal Alkynes to Cyclopropenes by a Chiral Gadolinium Catalyst, ACS Catal., 8 (2018) 4705-4709. (中科院一区，IF:13.700)

[8] Q.Q. Luo, Z. Tian, J. Tang, J. Wang, Y. Tian*, C. Peng, G. Zhan*, B. Han*, Design and Application of Chiral Bifunctional 4-Pyrrolidinopyridines: Powerful Catalysts for Asymmetric Cycloaddition of Allylic N-Ylide, ACS Catal., 12 (2022) 7221-7232. (中科院一区，IF:13.700)

[9] R. Zhou, J.S. Li, H.W. Cheo, R. Chua, G. Zhan, Z.M. Hou, J. Wu, Visible-light-mediated deuteration of silanes with deuterium oxide, Chem. Sci., 10 (2019) 7340-7344. (中科院一区，IF:9.969)

[10] H.J. Leng, Q. Zhao, Q. Mao, S.J. Liu, M.L. Luo, R. Qin, W. Huang*, G. Zhan*, NHC-catalysed retro-aldol/aldol cascade reaction enabling solvent-controlled stereodivergent synthesis of spirooxindoles, Chin. Chem. Lett., 32 (2021) 2567-2571. (中科院一区，IF:8.455)

[11] X. Tang, N. Zhang, G. He, C.H. Li, W. Huang, X.Y. Wang, G. Zhan*, B. Han*, Unconventional [2+3] Cyclization Involving [1,4]-Sulfonyl Transfer to Construct Polysubstituted Fluorazones as Inhibitors of Indoleamine 2,3-Dioxygenase 1, Org. Lett., 22 (2020) 7909-7914. (中科院一区，IF:6.072)

[12] X. Tang, Y.L. Wu, J. Jiang, H.Y. Fang, W.J. Zhou, W. Huang*, G. Zhan*, Formal (3+1+1) Carboannulation of Morita-Baylis-Hillman Carbonates with Pyridinium Ylides: Access to Spiro-Cyclopentadiene Oxindoles, Org. Lett., 23 (2021) 8937-8941. (中科院一区，IF:6.072)

[13] Q.W. Pang, J. Zhou, Y.L. Wu, W.J. Zhou, W.F. Zuo, G. Zhan*, B. Han*, Construction of Oxo-Bridged Diazocines via Rhodium-Catalyzed (4+3) Cycloaddition of Carbonyl Ylides with Azoalkenes, Org. Lett., 24 (2022) 1362-1366. (中科院一区，IF:6.072)

[14] M.L. Luo, Q.M. Hou, S.J. Liu, Q. Zhao, R. Qin, C. Peng, B. Han*, G. Zhan*, One-Step Synthesis of Hydropyrrolo[3,2-b]indoles via Cascade Reactions of Oxindole-Derived Nitrones with Allenoates, Org. Lett., 24 (2022) 8493-8497. (中科院一区，IF:6.072)

[15] D.A. Li, X.H. He, X. Tang, Y.L. Wu, H.L. Zhao, G. He, C. Peng, B. Han*, G. Zhan*, Organo/Silver Dual Catalytic (3+2)/Conia-Ene Type Cyclization: Asymmetric Synthesis of Indane-Fused Spirocyclopenteneoxindoles, Org. Lett., 24 (2022) 6197-6201. (中科院一区，IF:6.072)

[16] Z. Tian, J. Jiang, Z.H. Yan, Q.Q. Luo, G. Zhan*, W. Huang, X. Li*, B. Han*, Catalytic asymmetric [3+2] cycloaddition of pyrazolone-derived MBH carbonate: highly stereoselective construction of the bispiro-[pyrazolone-dihydropyrrole-oxindole] skeleton, Chem. Commun., 58 (2022) 5363-5366. (中科院一区，IF:6.065)

[17] B.H. Chen, S.J. Liu, Q. Zhao, Q.M. Hou, J.L. Yuan, G. Zhan, Q.Q. Yang*, W. Huang*, Palladium-catalyzed asymmetric [4+2] annulation of vinyl benzoxazinanones with pyrazolone 4,5-diones to access spirobenzoxazine frameworks, Chem. Commun., 59 (2023) 1233-1236. (中科院一区，6.065)

[18] R. Qin, Q. Zhao, B. Han, H.P. Zhu, C. Peng, G. Zhan*, W. Huang*, Indole-Based Small Molecules as Potential Therapeutic Agents for the Treatment of Fibrosis, Front. Pharmacol., 13 (2022). (中科院二区，IF:5.988)

[19] Y.Y. Ai, D.A. Li, G. Li, H.P. Li, X.H. He, X.J. Fu, Y.T. Wang, G. Zhan*, B. Han*, Asymmetric Synthesis of Spirocyclopentane Oxindoles via [2+3] Annulation with 2-(2-Oxoindolin-3-yl)malononitriles as 1,2-Carbon Bisnucleophiles, Adv. Synth. Catal., 363 (2021) 3283-3289. (中科院二区，IF:5.981)

[20] W.F. Zuo, J. Zhou, Y.L. Wu, H.Y. Fang, X.J. Lang, Y. Li, G. Zhan*, B. Han*, Synthesis of spiro(indoline-2,3 '-hydropyridazine) via an "on-water" [4+2] annulation reaction, Org. Chem. Front., 8 (2021) 922-927. (中科院一区，IF:5.456)

[22] J. Zhou, C. Chen, Q.W. Pang, W.F. Zuo, X. Li, G. Zhan, Q.Q. Yang*, B. Han*, Cooperative photoactivation/Lewis base catalyzed [4+2] annulations of alpha-diazoketones and ortho-amino MBH carbonates to access dihydroquinolinone frameworks, Org. Chem. Front., 10 (2023) 1034-1041. (中科院一区，IF:5.456)

[23] J. Tang, Z.H. Yan, G. Zhan*, Q.Q. Yang, Y.Y. Cheng, X. Li*, W. Huang*, Visible-light-mediated sequential Wolff rearrangement and Staudinger cycloaddition enabling the assembly of spiro-pyrazolone-beta-lactams, Org. Chem. Front., 9 (2022) 4341-4346. (中科院一区，IF:5.456) 

[24] C.H. Li, W.F. Zuo, J. Zhou, W.J. Zhou, M. Wang, X. Li, G. Zhan*, W. Huang*, Catalytic asymmetric synthesis of 3,4 '-indole-pyrazole derivatives featuring axially chiral bis-pentatomic heteroaryls, Org. Chem. Front., 9 (2022) 1808-1813. (中科院一区，IF:5.456)

[25] Q. Zhao, C. Peng, Y.-T. Wang, G. Zhan*, B. Han*, Recent progress on the construction of axial chirality through transition-metal-catalyzed benzannulation， Org. Chem. Front., 9 (2021) 2772–2785. (中科院一区，IF:5.456)

[26] X.H. He, X.J. Fu, G. Zhan*, N. Zhang, X. Li, H.P. Zhu, C. Peng, G. He*, B. Han*, Organocatalytic asymmetric synthesis of multifunctionalized alpha-carboline-spirooxindole hybrids that suppressed proliferation in colorectal cancer cells, Org. Chem. Front., 9 (2022) 1048-1055. (中科院一区，IF:5.456)

[27] G. Zhan, M.L. Shi, W.J. Lin, Q. Ouyang, W. Du, Y.C. Chen, Direct Asymmetric Aza-Vinylogous-Type Michael Additions of Nitrones from Isatins to Nitroalkenes, CHEMISTRY-A EUROPEAN JOURNAL, 23 (2017) 6286-6289. (中科院二区，IF:5.020)

[28] Q. Mao, Q. Zhao, M.Z. Li, R. Qin, M.L. Luo, J. Xue, B.H. Chen, H.J. Leng, C. Peng*, G. Zhan*, B. Han*, Construction of CF3-Functionalized Fully Substituted Benzonitriles through Rauhut-Currier Reaction Initiated [3+3] Benzannulation, J. Org. Chem., 86 (2021) 14844-14854. (中科院二区，IF:4.198)

[29] Q. Zhao, C. Peng, G. Zhan*, B. Han*, Synthesis of polysubstituted arenes through organocatalytic benzannulation, RSC ADVANCES, 10 (2020) 40983-41003. (中科院三区，IF:4.036)

[30] S.R. He, J. Wang, J.F. Zheng, Q.Q. Luo, H.J. Leng, S.X. Zheng, C. Peng, B. Han*, G. Zhan*, Organocatalytic (5+1) benzannulation of Morita-Baylis-Hillman carbonates: synthesis of multisubstituted 4-benzylidene pyrazolones, New J. Chem., 46 (2022) 11617-11622. (中科院三区，IF: 3.925)

[31] G. Li, X.H. He, H.P. Li, Q. Zhao, D.A. Li, H.P. Zhu, Y.H. Zhang, G. Zhan*, W. Huang*, Design, Synthesis, and Biological Evaluation of Tetrahydro-alpha-carbolines as Akt1 Inhibitors That Inhibit Colorectal Cancer Cell Proliferation, ChemMedChem., 17 (2022). (中科院三区，IF:3.540)

[32] H.J. Leng, Y.T. Wang, X.H. He, H.L. Xia, P.S. Xu, P. Xiang, Q.Q. He, G. Zhan*, W. Huang*, Design and Efficient Synthesis of RalA Inhibitors Containing the Dihydro-alpha-carboline Scaffold, ChemMedChem., 16 (2021) 851-859. (中科院三区，IF:3.540)

[33] M.L. Shi, G. Zhan, W. Du, Y.C. Chen, Direct Asymmetric Aza-Vinylogous Mannich Reaction of Nitrones from Isatins and Ketimines, Acta Chim. Sin., 75 (2017) 998-1002. (中科院三区，IF:2.789)

[34] G. Zhan, M.L. Shi, Q. He, W. Du, Y.C. Chen*, [4+3] Cycloadditions with Bromo-Substituted Morita-Baylis-Hillman Adducts of Isatins and N-(ortho-Chloromethyl)aryl Amides, Org. Lett., 17 (2015) 4750-4753.IF: (中科院一区，IF:6.072)

[35] M.L. Shi, G. Zhan, S.L. Zhou, W. Du, Y.C. Chen, Asymmetric Inverse-Electron-Demand Oxa-Diels-Alder Reaction of Allylic Ketones through Dienamine Catalysis, Org. Lett., 18 (2016) 6480-6483. (中科院一区，IF:6.072)

[36] Y.R. Chen, G. Zhan, W. Du, Y.C. Chen, Regioselective Asymmetric Formal (3+2) Cycloadditions of Nitrone Ylides from Isatins and Enals, Adv. Synth. Catal., 358 (2016) 3759-3764. (中科院二区，IF:5.981)

[37] W.J. Lin, G. Zhan, M.L. Shi, W. Du, Y.C. Chen, [3+3] Formal Cycloadditions of Nitrones from Isatins and Azaoxyallyl Cations for Construction of Spirooxindoles, Chin. J. Chem. 35 (2017) 857-860. (中科院二区，IF:5.560)